Document Type : Original Article

Authors

Department of Dentistry, Government Medical College, Jalaun, Uttar Pradesh, India

Abstract

INTRODUCTION: The study aims to measure and compare pulmonary function tests (PFTs) in oral
submucous fibrosis (OSMF) patients (smokers/nonsmokers) and normal individuals.
MATERIALS AND METHODS: The study population included 150 participants that comprised 50
nonsmoker OSMF patients, 50 OSMF patients who smoke as well, and 50 patients with no deleterious
habits. Spirometer was used to assess PFT.
RESULTS: Results showed that a significant P value was obtained for forced vital capacity (FVC),
forced expiratory volume in 1 s (FEV1), FEV1/FVC, peak expiratory flow rate (PEFR), and maximum
voluntary ventilation (MVV) and also for the predicted values of FEV, FEV1, FEV1/FVC, PEFR, and
MVV in OSMF (smokers/nonsmokers) study groups.
CONCLUSION: Thus, the decrease in pulmonary function can be an alarming sign for restrictive
type of pulmonary disease.

Keywords

1. Ali FM, Patil A, Patil K, Prasant MC. Oral submucous fibrosis and
its dermatological relation. Indian Dermatol Online J 2014;5:260-5.
2. Srivastava R, Jyoti B, Pradhan D, Siddiqui Z. Prevalence of oral
submucous fibrosis in patients visiting dental OPD of a dental
college in Kanpur: A demographic study. J Family Med Prim
Care 2019;8:2612-7.
3. Nigam NK, Aravinda K, Dhillon M, Gupta S, Reddy S,
Srinivas Raju M. Prevalence of oral submucous fibrosis among
habitual gutkha and areca nut chewers in Moradabad district.
J Oral Biol Craniofacial Res 2014;4:8-13.
4. Hazarey VK, Erlewad DM, Mundhe KA, Ughade SN. Oral
submucous fibrosis: Study of 1000 cases from central India. J Oral
Pathol Med 2007;36:12-7.
5. Gupta PC, Sinor PN, Bhonsle RB, Pawar VS, Mehta HC. Oral
submucous fibrosis in India: A new epidemic? Natl Med J India
1998;11:113-6.
6. Bhisey RA, Boucher BJ, Chen TH, Gajalakshmi V, Gupta PC,
Hecht SS. Betel-quid and areca-nut chewing and some areca-nut
derived nitrosamines. IARC Monogr Eval Carcinog Risks Hum
2004;85:1-334.
7. Khan S, Chatra L, Prashanth SK, Veena KM, Rao PK. Pathogenesis
of oral submucous fibrosis. J Cancer Res Ther 2012;8:199-203.
8. Wollina U, Verma SB, Ali FM, Patil K. Oral submucous fibrosis:
An update. Clin Cosmet Investig Dermatol 2015;8:193-204.
9. Gupta PC. Survey of sociodemographic characteristics of tobacco
use among 99,598 individuals in Bombay, India using handheld
computers. Tob Control 1996;5:114-20.
10. MillerWF, ScacciR, Gast LR. Laboratory Evaluation of Pulmonary
Function. Philadelphia: J.B. Lippincott; 1987.
11. Golshan M, Nemat BM. Normal prediction equations of
spirometric parameters in 799 healthy Iranian children and
adolescents. Arch Iran Med 2000;3:109-13.
12. Mukherjee Al, Biswass K. Oral sub-mucous fibrosis – A search
for etiology. Ind J Otolaryngol 1972;24:11.
13. Joshi SG. Submucous fibrosis of the pal-ate and pillars. Ind J
Otolaryngol 1952;4:110.
14. Schwartz J. Atrophiaidiopathica (tropica) Mucosa Oris. In:
Presented at the 11th International Dental Congress. London: 1952.
15. Pindborg JJ. Lesions of the oral mucosa to be considered
premalignant and their epidemiology. In: Mackenzie IC,
Dabelsteen E, Squier CA, editors. Oral Pre-Malignancy. Iowa
City: University of Iowa Press; 1980. p. 2-12.
16. Phatak AG. Oral submucousfibrosis. Nat Med J India1993;6:249-5.
17. Shah N, Sharma PP. Role of chewing and smoking habits in the
etiology of oral submucous fibrosis (OSF): A case-control study.
J Oral Pathol Med 1998;27:475-9.
18. Prasad BK, Sahay AP, Singh AK. Smoking women and their lung
function tests. Kathmandu Univ Med J 2003;2:142-4.
19. Padmavathy KM. Comparative study of pulmonary function
variables in relation to type of smoking. Indian J Physiol
Pharmacol 2008;52:193-6.
20. Available from: https://www.medscape.com/
answers/1413347-196705/what-is-peak-expiratory-flow-ratepefr. [last accessed on: 24 November, 2019].
21. Available from: https://en.wikipedia.org/wiki/Peak_
expiratory_flow. [last accessed on: 24 November, 2019].
22. Nivsarkar R, Deoghare A, Vishwakarma1 A, Salkar P. Pulmonary
function test in OSMF patients. Indian J Dent Sci 2020;12:33-5.
23. Datta S, Yanga JK. Comparison of the effects of chronic smoking
and betel nut chewing on the respiratory and cardiovascular
parameters in Melanesian male population. Med Sci Bull
2003;1:13-7.
24. KiyingiKS, SaweriA. Betelnut chewing causes bronchoconstriction
in some asthma patients. P N G Med J 1994;37:90-9.
25. Taylor RF, Al-Jarad N, John LM, Conroy DM, Barnes NC. Betelnut chewing and asthma. Lancet 1992;339:1134-6.
26. Wang TN, Huang MS, Lin MC, Duh TH, Lee CH, Wang CC, et al.
Betel chewing and arecoline affects eotaxin-1, asthma and lung
function. PLoS One 2014;9:e91889.
27. Wang FW, Tu MS, Chuang HY, Yu HC, Cheng LC, Hsu PI.
Erosive esophagitis in asymptomatic subjects: Risk factors. Dig
Dis Sci 2010;55:1320-4.
28. Deng JF, Ger J, Tsai WJ, Kao WF, Yang CC. Acute toxicities of
betel nut: Rare but probably overlooked events. J Toxicol Clin
Toxicol 2001;39:355-60.
29. Nelson BS, Heischober B. Betel nut: A common drug used by
naturalized citizens from India, Far East Asia, and the South
Pacific Islands. Ann Emerg Med 1999;34:238-43.