1 Department of Midwifery, School of Nursing and Midwifery, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran Health Sciences Research Center, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran

2 Department of Environmental Health, Army 550 Hospital, Mashhad, Iran


BACKGROUND AND AIM: Given the prevalence of novel coronavirus disease 2019 (COVID‑19)
and the lack of information on coronavirus and pregnancy, the purpose of this study was to evaluate
the association of COVID‑19 and perinatal outcomes in pregnant women.
MATERIALS AND METHODS: In the present review article, the search process was conducted on
English and Persian scientific databases of PubMed, Scopus, Google Scholar, Magiran, Irandoc,
Iranmedx, and SID as well as the websites of international organizations of World Health Organization
and Centers for Disease Control and Prevention using the main keywords of “Pregnancy,” “Perinatal
outcomes,” “Coronavirus,” “COVID‑19,” “MERS‑CoV,” “MERS,” “SARS‑CoV‑2,” and “SARS‑CoV‑1”
and their Persian‑equivalent keywords from inception until March 16 2020.
RESULTS: The findings of studies on mothers with COVID‑19 were limited, and insufficient information
is available on the adverse pregnancy outcomes in pregnant women with COVID‑19. In cases of
infection with other coronaviruses such as Middle East respiratory syndrome and severe acute
respiratory syndrome during pregnancy, there have been reports on adverse pregnancy outcomes
such as miscarriage, stillbirth, preterm labor, low birth weight, and congenital malformations following
high fever in the first trimester.
CONCLUSION: Pregnant women may be more susceptible to viral respiratory infections, including
COVID‑19, due to immunological and physiological changes. Therefore, pregnant women should
take routine preventive measures, such as washing their hands frequently and avoiding contact with
infected people, to prevent infection.


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