Document Type : Original Article


1 Department of Public Health, School of Health, Social Determinants of Health Research Center, Hamadan University of Medical Sciences, Hamadan, Iran

2 Department of Epidemiology, School of Health, Modeling of Noncommunicable Diseases Research Center, Hamadan University of Medical Sciences, Hamadan, Iran

3 Department of Psychiatry, School of Medicine, Research Center for Behavioral Disorders and Substance Abuse, Hamadan University of Medical Sciences, Hamadan, Iran, 4

4 Department of Behavioral and Environmental Health, School of Public Health, Jackson State University, Jackson, MS, USA


BACKGROUND: Substance use relapse after treatment is one of the most important aspects of
addiction. The present study aimed to investigate the factors affecting the substance use relapse
among Iranian addicts.
MATERIALS AND METHODS: This cross‑sectional study was conducted in 2019 on 396 addicts
referring to the addiction treatment centers in Hamadan, who were selected using a cluster random
sampling method. The data were collected by a two‑section questionnaire (demographic variables
and risk factors for substance abuse recurrence). The collected data were analyzed using descriptive
statistics and logistic regression analysis.
RESULTS: The participants’ mean (standard deviation) age was 36.56 (8.8) years, and 84.6%
of the participants had a history of relapse. The logistic regression analysis revealed that
marital status (odds ratio [OR] = 2.594; 95% confidence interval [CI]: 1.472–4.570), personal
willingness (OR = 8.186; 95% CI: 1.875–35.738), pleasure (OR = 2.738; 95% CI: 1.122–6.679), drug
availability (OR = 3.392; 95% CI: 1.023–11.247), family disputes (OR = 4.583; 95% CI: 1.345–15.609),
an addicted friend (OR = 2.693; 95% CI: 1.014–7.157), and close addicted relatives (OR = 3.513;95%
CI: 1.193–10.348) were the main predictors of addiction relapse (P < 0.05).
CONCLUSION: The present study confirmed the effect of several factors (namely demographic,
individual, interpersonal, environmental, and behavioral) on the substance use relapse. Accordingly,
designing and implementing some interventions based on the findings of the present study may
contribute to preventing substance use relapse.


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