Document Type : Original Article

Authors

1 School of Medicine, Kermanshah University of Medical Science, Kermanshah, Iran

2 Department of Vascular and Endovascular Surgery, Clinical Research Development Center, Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran,

3 Department of Biostatistics and Epidemiology, Faculty of Medicine, Kermanshah University of Medical Sciences, Kermanshah,

4 Department of Neurology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran

Abstract

BACKGROUND: Diabetes mellitus (DM) is one of the main public health troubles diabetic foot
ulcer (DFU) is one of the most important and relatively common causes of hospitalization. This study
investigates the prevalence of peripheral artery disease (PAD) in Imam Reza Hospital of Kermanshah
during 2017–2018.
MATERIALS AND METHODS: This study is descriptive‑analytical. The study population was
196 cases with infectious DFUs admitted to Imam Reza Hospital of Kermanshah during 2019–2020.
The presence or absence of PAD was assessed in these cases. The collected data were analyzed
by SPSS software (version 18.0).
RESULTS: Among 196 patients studied, 120 (61.22%) patients had PAD. The prevalence of
PAD was higher in men than in women and it was more common in Type 2 DM patients than in
Type 1 DM patients. The majority of ulcers were located on the nonplantar surface of the foot.
Moreover, the prevalence of PAD had a significant relationship by increasing the duration of
diabetes (P = 0.041), history of amputation (P = 0.002), history of diabetic foot (P = 0.006), and
peripheral neuropathy (P = 0.005).
CONCLUSION: A considerable number of diabetic patients with DFU had PAD. This necessitates
more intense interventions to manage PAD as a strong risk factor for DFU in diabetics. Neurovascular
assessment of diabetic patients and early diagnosis of PAD may be appropriate interventions to
prevent development of DFUs. We recommend trial studies to find out the best methods to address
early detection of PAD in diabetics.

Keywords

1. Tol A, Sharifirad G, Shojaezadeh D, Tavasoli E, Azadbakht L.
Socio‑economic factors and diabetes consequences among patients
with type 2 diabetes. J Educ Health Promot 2013;2:12.
2. Frykberg R, Habershaw G, Chrzan I. Epidemiology of the
diabetic foot: Ulcerations and amputations. In: Veves A, editor.
Contemporary Endocrinology: Clinical Management of Diabetic
Neuropathy. Totowa, NJ: Humana Press 1998; 1998. p. 273‑90.
3. Freikberg RG. Diabetic foot disorders: A clinical practice
guideline. J Foot Ankle Surg. 2006;45:S1‑66.
4. Reiber G, Boyko E, Smith D. Lower extremity foot ulcers and
amputations in diabetes. In: Harris M, Cowie C, Stem M, editors.
Diabetes in America. 2nd ed. Washington DC: NIH Publication;
1995. p. 409‑28.
5. Mohammadi M, Ziapoor A, Mahboubi M, Faroukhi A, Amani N,
Hydarpour F, Anbari SZ, Esfandnia A. Performance evaluation
of hospitals under supervision of kermanshah medical sciences
using pabonlasoty diagram of a five-year period (2008-2012). Life
Sci J. 2014;11:77-81.
6. Abbott CA, Vileikyte L, Williamson S, Carrington AL, Boulton AJ.
Multicenter study of the incidence of and predictive risk factors for
diabetic neuropathic foot ulceration. Diabetes Care 1998;21:1071‑5.
7. Walters DP, Gatling W, Mullee MA, Hill RD. The distribution
and severity of diabetic foot disease: A community study with
comparison to a non‑diabetic group. Diabet Med 1992;9:354‑8.
8. Ramsey SD, Newton K, Blough D, McCulloch DK, Sandhu N,
Reiber GE, et al. Incidence, outcomes, and cost of foot ulcers in
patients with diabetes. Diabetes Care 1999;22:382‑7.
9. Holzer SE, Camerota A, Martens L, Cuerdon T, Crystal‑Peters J,
Zagari M. Costs and duration of care for lower extremity ulcers
in patients with diabetes. Clin Ther 1998;20:169‑81.
10. Kaboudi M, Dehghan F, Ziapour A. The effect of acceptance and
commitment therapy on the mental health of women patients with
type II diabetes. Ann Trop Med Public Health 2017;10:1709‑13.
11. Larijani B, Forouzandeh F. Diabetic foot disorders. Iran J Diabet
Metabol 2003;2:93‑103.
12. Muthiah A, Kandasamy R, Nagulan S, Madasamy A. A study on
diabetic foot and its association with peripheral artery disease.
Int Surgery J 2017;4:1217‑21.
13. Elgzyri T, Larsson J, Thörne J, Eriksson KF, Apelqvist J. Outcome
of ischemic foot ulcer in diabetic patients who had no invasive
vascular intervention. Eur J Vasc Endovasc Surg 2013;46:110‑7.
14. Forouzandeh F, Aziz Ahari A, Abolhasani F, Larijani B. Evaluation
of foot neurovascular status in diabetic patients referred to
diabetes clinic of Dr. Shariati Hospital, 2003‑2004. Iran J Diabet
Metabol 2005;4:43‑51.
15. Mashayekhi M, Larijani B, Mohajeri M, Rambod K. Frequency of
amputation in patients with diabetic foot ulcers were hospitalized
in Shariati Hospital in 2002‑2011 years. Iran J Diabet Lipid Disord
2013;12:543‑54.
16. Prompers L, Schaper N, Apelqvist J, Edmonds M, Jude E,
Mauricio D, et al. Prediction of outcome in individuals with
diabetic foot ulcers: Focus on the differences between individuals
with and without peripheral arterial disease. The EURODIALE
study. Diabetologia 2008;51:747‑55.
17. Azar FE, Solhi M, Darabi F, Rohban A, Abolfathi M,
Nejhaddadgar NJD. Effect of educational intervention based on
PRECEDE‑PROCEED model combined with self‑management
theory on self‑care behaviors in type 2 diabetic patients. Diabet
Metabo Syndrome: Clin Res 2018;12(6):1075‑8.
18. Abbott CA, Carrington AL, Ashe H, Bath S, Every LC, Griffiths J,
et al. The north‑west diabetes foot care study: Incidence of, and
risk factors for, new diabetic foot ulceration in a community‑based
patient cohort. Diabet Med 2002;19:377‑84.
19. Hinchliffe RJ, Forsythe RO, Apelqvist J, Boyko EJ, Fitridge R,
Hong JP, Katsanos K, Mills JL, Nikol S, Reekers J, Venermo M.
Guidelines on diagnosis, prognosis, and management of
peripheral artery disease in patients with foot ulcers and
diabetes (IWGDF 2019 update). Diabetes/Metabolism Research
and Reviews. 2020;36:e3276.
20. Franklin GM, Shetterly SM, Cohen JA, BaxterJ, Hamman RF. Risk
factors for distal symmetric neuropathy in NIDDM. The san luis
valley diabetes study. Diabetes Care 1994;17:1172‑7.
21. Fincke BG, Miller DR, Turpin R. A classification of diabetic
foot infections using ICD‑9‑CM codes: Application to a large computerized medical database. BMC Health Serv Res
2010;10:192.
22. Dehkhoda S, Arianpour N, Akbarzadeh M. Evaluation of effective
factors in treatment outcome of diabetic foot in diabetic patients
referring to Taleghany Hospital‑Tehran from. Ann Militar Health
Sci Res 2011;9:99‑104.
23. Lavery LA, Armstrong DG, Peters EJ, Lipsky BA. Probe‑to‑bone
test for diagnosing diabetic foot osteomyelitis: Reliable or relic?
Diabetes Care 2007;30:270‑4.
24. Kumar S, Ashe HA, Parnell LN, Fernando DJ, Tsigos C, Young RJ,
et al. The prevalence of foot ulceration and its correlates in
type 2 diabetic patients: A population‑based study. Diabet Med
1994;11:480‑4.
25. Al Kafrawy NA, Mustafa EA, Abd El‑Salam AE, Ebaid OM,
Zidane OM. Study of risk factors of diabetic foot ulcers. Menoufia
Med J 2014;27:28.
26. Bakri FG, Allan AH, Khader YS, Younes NA, Ajlouni KM.
Prevalence of diabetic foot ulcer and its associated risk factors
among diabetic patients in Jordan. Jordan Med J 2012;171:1‑16.
27. Dinh MT, Abad CL, Safdar N. Diagnostic accuracy of the
physical examination and imaging tests for osteomyelitis
underlying diabetic foot ulcers: Meta‑analysis. Clin Infect Dis
2008;47:519‑27.
28. Schade V, Andersen C, Omana‑Daniels R. How fluorescence
angiography illuminates the potential for limb salvage. Podiatr
Tod 2015;28:20‑4.