Document Type : Original Article
Authors
1 Department of Statistics and Epidemiology, School of Health, Isfahan University of Medical Sciences, Isfahan
2 Department of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Abstract
Background: Some studies have shown that increased rate of iron stores even in a normal
range may increase cardiovascular diseases (CVDs) in some individuals. Lipid disorders are
also the risk factors for CVDs. Therefore, the question is whether or not iron store is correlated
with lipid profile, this study evaluates the association between dietary iron, iron stores and serum
lipid profiles. Materials and Methods: This cross-sectional study was done on 82 healthy
university students and university staff females in Isfahan University of Medical Sciences who
were in reproductive age and announced their readiness to participate in the study. Serum
ferritin concentration, components of lipid profile, blood glucose, and insulin were measured in
all the subjects. Dietary intake was assessed by semi-quantitative food frequency questionnaire.
Data analysis was done through SPSS software, version 18. Results: Pearson correlation
test showed a positive and significant correlation between serum ferritin concentration levels
with triglyceride (r = 0.278; P = 0.006), total cholesterol (r = 0.267; P = 0.008), and blood
glucose (r = 0.275; P = 0.006); however, the correlation between serum ferritin, high-density
lipoprotein-cholesterol, low-density lipoprotein-cholesterol, and insulin was not significant.
After adjustment of confounding factors, only the significant correlation occurred for blood
glucose (P = 0.016). Before and after adjustment of confounding factors, there was no
significant correlation between hemoglobin and hematocrit with concentration of lipid profile
components, glucose and insulin. Before and after adjustment of confounding factors, there
was no significant correlation between total amount of iron, heme iron, and non-heme dietary
iron with concentration of lipid profile components, glucose and insulin. Conclusion: According
to the current study, serum ferritin is directly and significantly correlated with concentration of
fasting blood glucose, which emphasized on the amount of iron store with blood glucose even
in healthy people. The results of the present study indicate no significant correlation between
iron store and dietary iron intake with lipid
parameters and insulin. Conducting more
extensive epidemiologic studies in men and
other age groups is recommended.
Keywords
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