Authors

1 Amala Institute of Medical Sciences, Thrissur, Kerala, India

2 Clinical Sciences Division, Northern Ontario School of Medicine, Sudbury, Ontario, Canada, Department of Internal Medicine, Health Sciences North Research Institute, Sudbury, Ontario, Canada

Abstract

BACKGROUND: Vaccine hesitancy leads to an increase in morbidity, mortality, and health‑care 
burden. Reasons for vaccine hesitancy include anti‑vax group statements, misinformation about 
vaccine side effects, speed of vaccine development, and general disbelief in the existence of viruses 
like COVID‑19. Medical students are future physicians and are key influencers in the uptake of 
vaccines. Hence, investigating vaccine hesitancy in this population can help to overcome any barrier 
in vaccine acceptance.
METHODS: In this paper, we review five articles on COVID‑19 vaccine hesitancy in medical students 
and consider potential future research. All published papers relevant to the topic were obtained 
through extensive search using major databases. Inclusion criteria included studies that specifically 
investigated COVID‑19 vaccine hesitancy in medical students published between 2020 and 2021. 
Exclusion criteria included studies that investigated vaccine hesitancy in health‑care professionals, 
allied health, and viruses apart from COVID‑19. A total of 10 studies were found from our search.
RESULTS: Based on our exclusion criteria, only five studies were included in our review. The sample 
size ranged from 168 to 2133 medical students. The percentage of vaccine hesitancy in medical 
students ranged from 10.6 to 65.1%. Reasons for vaccine hesitancy included concern about serious 
side effects, vaccine efficacy, misinformation and insufficient information, disbelief in public health 
experts, financial costs, and belief that they had acquired immunity.
CONCLUSION: These results suggest that vaccine hesitancy is an important cause of the incidence 
and prevalence of COVID‑19 cases. Identifying the barriers of vaccine hesitancy in prospective 
physicians can help increase vaccination uptake in the general public. Further research is necessary 
to identify the root cause of these barriers.

Keywords

1. World Health Organization. (2019, December 5). Immunization. 
Retrieved June 3, 2021, from https://www.who.int/news‑room/
facts‑in‑pictures/detail/immunization.
2. MacDonald NE; SAGE Working Group on Vaccine Hesitancy. 
Vaccine hesitancy: Definition, scope and determinants. Vaccine 
2015;33:4161‑4.
3. Kashte S, Gulbake A, El‑Amin Iii SF, Gupta A. COVID‑19 
vaccines: Rapid development, implications, challenges and future 
prospects. Hum Cell 2021;34:711‑33.
4. Lucia VC, Kelekar A, Afonso NM. COVID‑19 vaccine hesitancy 
among medical students. J Public Health 2020;43:445‑9.
5. Saied SM, Saied EM, Kabbash IA, Abdo SA. Vaccine hesitancy: 
Beliefs and barriers associated with COVID-19 vaccination among 
Egyptian medical students. J Med Virol 2021;93:4280‑91.
6. Kanyike AM, Olum R, Kajjimu J, Ojilong D, Akech GM, 
Nassozi DR, et al. Acceptance of the coronavirus disease‑2019 
vaccine among medical students in Uganda. Trop Med Health 
2021;49:1‑11.
7. Jain J, Saurabh S, Kumar P, Verma MK, Goel AD, Gupta MK, et al. 
COVID‑19 vaccine hesitancy among medical students in India. 
Epidemiol Infect 2021;149:e132.
8. Kelekar AK, Lucia VC, Afonso NM, Mascarenhas AK. COVID‑19 
vaccine acceptance and hesitancy among dental and medical 
students. J Am Dent Assoc 2021;152:596‑603.
9. Patelarou E, Galanis P, Mechili EA, Argyriadi A, Argyriadis A, 
Asimakopoulou E, et al. Factors influencing nursing students' 
intention to accept COVID-19 vaccination – A pooled analysis of 
seven countries. medRxiv 2021.
10. Sallam M, Dababseh D, Eid H, Al‑Mahzoum K, Al‑Haidar A, 
Taim D, et al. High rates of COVID‑19 vaccine hesitancy and its 
association with conspiracy beliefs: A study in Jordan and Kuwait 
among other Arab countries. Vaccines 2021;9:42.
11. Betsch C, Wicker S. E‑health use, vaccination knowledge and 
perception of own risk: Drivers of vaccination uptake in medical 
students. Vaccine 2012;30:1143‑8.
12. Razai MS, Osama T, McKechnie DG, Majeed A. COVID‑19 vaccine 
hesitancy among ethnic minority groups. BMJ 2021;372:n513.
13. Robertson E, Reeve KS, Niedzwiedz CL, Moore J, Blake M, 
Green M, et al. Predictors of COVID‑19 vaccine hesitancy in the UK 
household longitudinal study. Brain Behav Immun 2021;94:41‑50.
14. Sun S, Lin D, Operario D. Interest in COVID‑19 vaccine trials 
participation among young adults in China: Willingness, reasons 
for hesitancy, and demographic and psychosocial determinants. 
Prev Med Rep 2021;22:101350.
15. Rostkowska OM, Peters A, Montvidas J, Magdas TM, Rensen L, 
Zgliczyński WS, et al. Attitudes and knowledge of european 
medical students and early graduates about vaccination and 
self‑reported vaccination coverage – Multinational cross‑sectional 
survey. Int J Environ Res Public Health 2021;18:3595.
16. Kumar R, Bairwa M, Beniwal K, Kant R. COVID‑19 vaccine 
acceptability, determinants of potential vaccination, and hesitancy 
in public: A call for effective health communication. J Edu Health 
Promot 2021;55:56.
17. Ain SN, Ahmad R, Qulsum R, Gilani MA. Potential vaccine 
hesitancy regarding COVID‑19 vaccines in Kashmiri population. 
J Edu Health Promot 2021;10:436.