Document Type : Original Article
Authors
- . Jafar Shahbazpour
- . Mohammad Abbasi 1
- . Narges Eskandari 2
- . Mohammad Aghaali 3
- . Reza Norouzadeh 4
1 Department of Nursing, School of Nursing, Qom University of Medical Sciences, Qom, Iran
2 Department of Midwifery, School of Medicine, Qom University of Medical Sciences, Qom, Iran
3 Department of Family and Community Medicine, School of Medicine, Neuroscience Research Center Qom University of Medical Sciences, Qom, Iran
4 Department of Nursing, School of Nursing and Midwifery, Shahed University, Tehran, Iran
Abstract
BACKGROUND: Delay in seeking medical help in patients with acute myocardial infarction (AMI)
challenges the patients in terms of diagnosis and treatment. This study aimed to evaluate the outcomes
of delay referral (≥12 h) in patients with AMI.
MATERIALS AND METHODS: In this retrospective cohort study, the medical records of 252 patients
with AMI (2017–2019) admitted to Shahid Beheshti Hospital, Qom, Iran, was reviewed. Data
collection tool was a researcher‑made data sheet that included demographic characteristics, times,
hospitalization costs, risk factors, history of heart disease, results of paraclinical tests, clinical
information at the time of admission, and outcomes of delayed referral. Data were analyzed using t‑test,
Chi‑square, Kaplan–Meier estimator, log‑rank test, Cox regression by STATA, and SPSS (version 25).
RESULTS: The levels of troponin, creatine phosphokinase, lactate dehydrogenase were
significantly higher in the delayed referral group (P < 0.05). After treatment, the cardiac ejection
fraction was significantly different in the nondelayed referral (41.56 ± 9.16) and the delayed referral
group (38.39 ± 11.01) (P < 0.001). There was no significant difference in the percentage of hospital
deaths in the groups (P = 0.078).
CONCLUSION: Delayed referral of patients with AMI is associated with decreased physiological
cardiac function, which complicates recovery for these patients.
Keywords
Factors predicting nutritional knowledge, illness perceptions,
and dietary adherence among hypertensive middleaged women: Application of transtheoretical model. J Educ Health
Promot 2021;10:212.
2. Shakibazadeh E, Sabouri M, Mohebbi B, Tol A, Yaseri M. Validity
and reliability properties of the Persian version of perceived health
competence scale among patients with cardiovascular diseases.
J Educ Health Promot 2021;10;19.
3. Ioacara S, PopescuAC, Tenenbaum J, DimulescuDR, PopescuMR,
Sirbu A, Fica S. Acute myocardial infarction mortality rates and
trends in Romania between 1994 and 2017. Int. J. Environ. Res.
Public Health 2020;17 (1):285.
4. Reed GW, Rossi JE, Cannon CP. Acute myocardial infarction. The
Lancet 2017 14;389 (10065):197‑210 Acute myocardial infarction.
The Lancet. 2017 Jan 14;389 (10065):197‑210.
5. Chai LS, Putit Z, Siop S. Barriers to timely treatment‑seeking
in patients with acute myocardial infarction in Malaysia:
A qualitative study. BMC nursing 2016;15 (1):1‑0.
6. Lim SC, Rahman A, Yaacob NM. Pre‑hospital factors influencing
time of arrival at emergency departments for patients with
acute ST‑elevation myocardial infarction. Malays J Med Sci
2019;26 (1):87.
7. Ibañez EL, López RR, Palavecino JA, Amicone NC. Evaluation of
Strategies to Reduce Reperfusion Times in ST‑Segment elevation
acute Myocardial infarction. Mobile health experience (mhealth).
Rev Argent Cardiol 2019;87:314‑8.
8. Rafi A, Sayeed Z, Sultana P, Aik S, Hossain G. Pre‑hospital delay
in patients with myocardial infarction: An observational study
in a tertiary care hospital of northern Bangladesh. BMC Health
Serv Res 2020;20 (1):1.
9. Soltani L, Ravari A, Sabzevari S. Relationship between
prodromal (warning) symptoms and referring time in patients
with myocardial infarction. Iran J Cardiovasc Nurs 2016;4:22‑31.
10. Xie L, Huang SF, Hu YZ. Factors influencing pre‑hospital patient
delay in patients with acute myocardial infarction. Chin Nurs Res
2015;2:75‑9.
11. Balk M, Gomes HB, Quadros AS, Saffi MA, Leiria TL.
Comparative analysis between transferred and self‑referred
STEMI patients undergoing primary angioplasty. Arq Bras
Cardiol 201915;112:402.
12. Lassen JF, Bøtker HE, Terkelsen CJ. Timely and optimal treatment
of patients with STEMI. Nat Rev Cardiol 2013;10 (1):41‑8.
13. Hochberg CP, Jacobs AK. Prehospital delay in patients with
ST‑segment elevation myocardial infarction: Time for change.
Coron Artery Dis 2018;29 (5):368‑70.
14. Maruhashi T, Ishihara M, Inoue I, Kawagoe T, Shimatani Y,
Kurisu S, Nakama Y, Kagawa E, Dai K, Matsushita J, Ikenaga H.
Effect of prodromal angina pectoris on the infarct progression in
patients with first ST‑elevation acute myocardial infarction. Circ
J 2010:1006150773.
15. Nguyen HL, Saczynski JS, Gore JM, Goldberg RJ. Age and sex
differences in duration of prehospital delay in patients with acute
myocardial infarction: A systematic review. Circ Cardiovasc Qual
Outcomes 2010;3 (1):82‑92.
16. McNair PW, Bilchick KC, Keeley EC. Very late presentation in
ST elevation myocardial infarction: Predictors and long‑term
mortality. IJC Heart & Vasculature 2019;22:156‑9.
17. O’gara PT, Kushner FG, Ascheim DD, Casey DE, Chung MK,
De Lemos JA, Ettinger SM, Fang JC, Fesmire FM, Franklin BA,
Granger CB. 2013 ACCF/AHA guideline for the management
of ST‑elevation myocardial infarction: A report of the
American College of Cardiology Foundation/American Heart
Association Task Force on Practice Guidelines. J Am Coll Cardiol
2013;61 (4):e78‑140.
18. Ängerud KH, Sederholm Lawesson S, Isaksson RM, Thylén I,
Swahn E. Differences in symptoms, first medical contact and
pre‑hospital delay times between patients with ST‑ and
non‑ST‑elevation myocardial infarction. Eur Heart J Acute
Cardiovasc Care 2019;8 (3):201‑7.
19. Dianati M, Mosavi GA, Hajibagheri A, Alavi NM. The pre‑hospital
delay in seeking treatment in patients with acute myocardial
infarction referring to a central hospital in Kashan, Iran. Indian J
Med Sci2010;64 (10):448‑54.
20. Rad M, Bidi A, Khaligh RG, Rad M. Causes of late referral to the
Emergency Department in patients with myocardial infarction in
Iran. Acta Facult Med Naissensis 2018;35:105‑13.
21. CerratoE, FornoD, FerroS, ChinagliaA. Characteristics, in‑hospital
management and outcome of late acute ST‑elevation myocardial
infarction presenters. J Cardiovasc Med 2017;18 (8):567‑71.
22. Nymark C, Henriksson P, Mattiasson AC, Saboonchi F,
Kiessling A. Inability to act was associated with an extended
delay prior to care‑seeking, in patients with an acute myocardial
infarction. Eur J Cardiovasc Nurs 2019;18 (6):512‑20.
23. Jäger B, Farhan S, Rohla M, Christ G, Podczeck‑Schweighofer A,
SchreiberW, LaggnerAN, Weidinger F, StefenelliT, Delle‑KarthG,
Kaff A. Clinical predictors of patient related delay in the VIENNA
ST‑elevation myocardial infarction network and impact on
long‑term mortality. E Eur Heart J Acute Cardiovasc Care
2017;6 (3):254‑61.
24. Ibanez B, James S, Agewall S, Antunes MJ, Bucciarelli‑Ducci C,
Bueno H, et al. 2017 ESC Guidelines for the management of acute
myocardial infarction in patients presenting with ST‑segment
elevation: The Task Force for the management of acute myocardial
infarction in patients presenting with ST‑segment elevation of the
European Society of Cardiology (ESC). European Heart Journal
2017;39 (2):119‑77.