Document Type : Original Article


1 Department of Oral Medicine and Radiology, DJ College of Dental Sciences and Research, Modinagar, Uttar Pradesh,

2 Departments of Oral Medicine and Radiology, Oral Pathology

3 Department of Preventive and Community Dentistry, PDM Dental College, Bahadurgarh, Haryana, India

4 Departments of Oral Medicine and Radiology, Public Health Dentistry, MB Kedia Dental College and Teaching Hospital, Birgunj, Nepal


BACKGROUND: Preterm low birth weight (PLBW) is a leading perinatal problem in developing
countries. PLBW is considered as a leading cause of neonatal death in the 1st year of life, with problems
in childhood and adulthood. Several studies have suggested a possible relationship between PLBW
and periodontal status of the expectant mothers. The present study was conducted to determine the
association between the maternal periodontitis and the low birth weight (BW) of the babies.
MATERIALS AND METHODS: This study consisted of 200 primipara mothers ranging between
18 and 35 years old, with a mean age of 23.96 years. The mothers were categorized based on the
weight of the infants as cases (BW <2500 g) and as controls (BW ≥2500 g). Age, mean weight,
height, body mass index, and periodontal status of the mothers as well as weight of the babies were
recorded. Periodontal parameters were assessed using the community periodontal index (CPI). The
data were recorded, analyzed, and statistically compared using the Chi‑square test (χ2
RESULTS: BW of the babies was regressed against CPI. Periodontitis was significantly associated
with decrease in BW of the babies (P < 0.0001).
CONCLUSION: Our findings showed an association of maternal periodontal disease with PLBW that
emphasizes to promote good oral hygiene of the expectant mothers during routine prenatal visits.


1. Jeffcoat MK, Hauth JC, Geurs NC, Reddy MS, Cliver SP,
Hodgkins PM, et al. Periodontal disease and preterm birth: Results
of a pilot intervention study. J Periodontol 2003;74:1214‑8.
2. Offenbacher S, Katz V, Fertik G, Collins J, Boyd D, Maynor G,
et al. Periodontal infection as a possible risk factor for preterm
low birth weight. J Periodontol 1996;67:1103‑13.
3. Jiang H, Su Y, Xiong X, Harville E, Wu H, Jiang Z, et al. Prevalence
and risk factors of periodontal disease among pre‑conception
Chinese women. Reprod Health 2016;13:141.
4. Islam MM. Increasing incidence of infants with low birth weight
in Oman. Sultan Qaboos Univ Med J 2015;15:e177‑83.
5. Offenbacher S, Jared HL, O’Reilly PG, Wells SR, Salvi GE,
Lawrence HP, et al. Potential pathogenic mechanisms of
periodontitis associated pregnancy complications. Ann
Periodontol 1998;3:233‑50.
6. Kunnen A, van Pampus MG, Aarnoudse JG, van der Schans CP,
Abbas F, Faas MM. The effect of Porphyromonas gingivalis
lipopolysaccharide on pregnancy in the rat. Oral Dis
7. Kothiwale S, Panwar V. Poor periodontal health of pregnant
women as a risk factor for preterm and low birth weight. Indian
J Dent 2011;2:129‑33.
8. Peter S. Essentials of Preventive and Community Dentistry.
4th edition. New Delhi: Arya (Medi) Publishing House; 2006.
9. World Health Organization. Preterm Birth. Available from: [Last
accessed on 2015 Oct 06].
10. Cheong JL, Doyle LW. Increasing rates of prematurity and
epidemiology of late preterm birth. J Paediatr Child Health
11. Lunardelli AN, Peres MA. Is there an association between
periodontal disease, prematurity and low birth weight? A
population‑based study. J Clin Periodontol 2005;32:938‑46.
12. Marin C, Segura‑Egea JJ, Martínez‑Sahuquillo A, Bullón P.
Correlation between infant birth weight and mother’s periodontal
status. J Clin Periodontol 2005;32:299‑304.
13. Sánchez AR, Bagniewski S, Weaver AL, Vallejos N. Correlations
between maternal periodontal conditions and preterm low birth
weight infants. J Int Acad Periodontol 2007;9:34‑41.
14. Moliterno LF, Monteiro B, Figueredo CM, FischerRG. Association
between periodontitis and low birth weight: A case‑control study.
J Clin Periodontol 2005;32:886‑90.
15. Bosnjak A, Relja T, Vucićević‑Boras V, Plasaj H, Plancak D.
Pre‑term delivery and periodontal disease: A case‑control study
from Croatia. J Clin Periodontol 2006;33:710‑6.
16. Zadeh‑Modarres S, Amooian B, Bayat‑Movahed S, Mohamadi M.
Periodontal health in mothers of preterm and term infants. Taiwan
J Obstet Gynecol 2007;46:157‑61.
17. ChakkiBA, Ealla KR, Hunsingi P, KumarA, Manidanappanavar P.
Influence of maternal periodontal disease as a risk factor for low
birth weight infants in Indian population. J Contemp Dent Pract
18. Khader Y, Al‑shishani L, Obeidat B, Khassawneh M, Burgan S,
Amarin ZO, et al. Maternal periodontal status and preterm low
birth weight delivery: A case‑control study. Arch Gynecol Obstet
19. Shanthi V, Vanka A, Bhambal A, Saxena V, Saxena S, Kumar SS. Association of pregnant women periodontal status to preterm
and low‑birth weight babies: A systematic and evidence‑based
review. Dent Res J (Isfahan) 2012;9:368‑80.
20. Vergnes JN, Sixou M. Preterm low birth weight and maternal
periodontal status: A meta‑analysis. Am J Obstet Gynecol
21. Baskaradoss JK, Geevarghese A, Kutty VR. Maternal periodontal
status and preterm delivery: A hospital based case‑control study.
J Periodontal Res 2011;46:542‑9.
22. BehrmanRE, Butler AS. Preterm Birth: Causes, Consequences, and
Prevention. Washington, DC: National Academies Press; 2007.
23. Goldenberg RL, Culhane JF, Iams JD, Romero R. Epidemiology
and causes of preterm birth. Lancet 2008;371:75‑84.
24. Romero R, Dey SK, Fisher SJ. Preterm labor: One syndrome, many
causes. Science 2014;345:760‑5.
25. Vinturache AE, Gyamfi‑Bannerman C, Hwang J, Mysorekar IU,
Jacobsson B; Preterm Birth International Collaborative (PREBIC).
Maternal microbiome – A pathway to preterm birth. Semin Fetal
Neonatal Med 2016;21:94‑9.
26. Walia M, Saini N. Relationship between periodontal diseases and
preterm birth: Recent epidemiological and biological data. Int J
Appl Basic Med Res 2015;5:2‑6.
27. Perunovic ND, Rakic MM, Nikolic LI, Jankovic SM, Aleksic ZM,
PlecasDV, et al. The association between periodontal inflammation
and labor triggers (Elevated cytokine levels) in preterm birth:
A cross‑sectional study. J Periodontol 2016;87:248‑56.
28. Tellapragada C, Eshwara VK, Bhat P, Acharya S, Kamath A,
Bhat S, et al. Risk factors for preterm birth and low birth weight
among pregnant Indian women: A hospital‑based prospective
study. J Prev Med Public Health 2016;49:165‑75.