Document Type : Original Article


1 Traditional and Complementary Medicine Research Center, Addiction Institute, Mazandaran University of Medical Sciences

2 Diabetes Research Center, Nursing and Midwifery Nasibeh School, Mazandaran University of Medical Sciences

3 Social Determinants of Health Research Center, Birjand University of Medical Sciences, Birjand, Iran

4 Traditional and Complementary Medicine Research Center, Addiction Institute, Mazandaran University of Medical Sciences,


BACKGROUND: Coronavirus (COVID‑19) is an infectious respiratory disease. Quarantine is often
accompanied by unpleasant experiences for those who go through it. The aim of this study was to
determine the mental health status of people during quarantine in northern Iran.
MATERIALS AND METHODS: This cross‑sectional study was conducted during the quarantine
period of coronavirus. Conventional sampling was done from March 6 to April 6. Six hundred and
forty‑two individuals were included. Inclusion criteria were living in Sari and being home quarantined
during the corona outbreak. Exclusion criteria included hospitalization history due to corona and
unwillingness to participate in the study. In this study, the General Health Questionnaire‑28 was used
online to collect the required data. To analyze the data, descriptive and inferential statistics (t‑test,
analysis of variance, and correlation coefficient) were used.
RESULTS: In this study, individuals were included in the investigation with a mean age of
38.74 ± 11.89 (ranged from 15 to 73). Most of the participants were female (72.85%) and
married (71.34%). According to the results, 21.5% of the participants had poor mental health.
Mean mental health scores have a statistically significant relationship with gender, marital status,
education, occupation, quarantine period, patients with corona, and exposure to a patient with
corona (P ≤ 0.05). Furthermore, a negative correlation coefficient was observed between age and
mental health score (correlation coefficient = −0.31, significance >0.001).
CONCLUSION: The average score of mental health has a significant relationship with gender, marital
status, education, occupation, quarantine period, corona, and exposure to a patient with corona.
Given the high prevalence of mental disorders in people during the COVID‑19 epidemic, educating
people and planning to reduce the psychological effects of the epidemic can be helpful.


1. Lipsitch M, Swerdlow DL, Finelli L. Defining the Epidemiology
of COVID‑19 ‑ Studies Needed. N Engl J Med 2020;382:1194‑6.
2. Kakemam E, Ghoddoosi-Nejad D, Chegini Z, Momeni K,
Salehiniya H, Hassanipour S, et al. Knowledge, Attitudes, and
Practices Among the General Population During COVID-19
Outbreak in Iran: A National Cross-Sectional Online Survey.
Front Public Health. 2020 Dec 10;8:585302. doi: 10.3389/
fpubh.2020.585302. PMID: 33363083; PMCID: PMC7758225.
3. Alkatout I, Biebl M, Momenimovahed Z, Giovannucci E,
Hadavandsiri F, Salehiniya H, Allahqoli L. Has COVID-19
Affected Cancer Screening Programs? A Systematic Review. Front
Oncol. 2021 May 17;11:675038. doi: 10.3389/fonc.2021.675038.
PMID: 34079764; PMCID: PMC8165307.
4. Azarkar Z, Salehiniya H, Kazemi T, Abbaszadeh H.
Epidemiological, imaging, laboratory, and clinical characteristics
and factors related to mortality in patients with COVID-19:
A single-center study. Osong Public Health Res Perspect.
2021;12:169-76. doi: 10.24171/j.phrp.2021.0012. Epub 2021 May
26. PMID: 34102047; PMCID: PMC8256296.
5. Saffarinia M. The prediction of mental health based on the anxiety
and the social cohesion that caused by coronavirus. Soc Psychol
Res 2020;9:129‑41.
6. Centers for Disease Control and Prevention. Quarantine and
Isolation; 2017. Available from:
/index.html. [Last accessed on 2020 Jan 30].
7. Barbisch D, Koenig KL, Shih FY. Is there a case for quarantine?
Perspectives from SARS to Ebola. Disaster Med Public Health
Prep 2015;9:547‑53.
8. Miles SH. Kaci Hickox: Public Health and the Politics of Fear;
2014. Available from:
kaci‑hickox‑public‑health‑and‑thepolitics‑of‑fear/. [Last accessed
on 2020 Jan 31].
9. Twu SJ, Chen TJ, Chen CJ, Olsen SJ, Lee LT, Fisk T, et al. Control
measures for severe acute respiratory syndrome (SARS) in
Taiwan. Emerg Infect Dis 2003;9:718‑20.
10. Wu YT, Zhang C, Liu H, Duan CC, Li C, Fan JX, et al. Perinatal
depression of women along with 2019 novel Coronavirus
breakout in China [Internet]. 2020 [Updated 2020 February
17]. Available from:
cfm?abstract_id=3539359 [DOI: 10.2139/ssrn.3539359].
11. Luna Sun, Zhuoer Sun, Lili Wu, Zhenwen Zhu, Fan Zhang, Zhilei
Shang, et al. Prevalence and Risk Factors of Acute Posttraumatic
Stress Symptoms during the COVID‑19 Outbreak in Wuhan,
China. medRxiv; 2020. DOI: 10.1101/2020.03.06.20032425.
12. Goldberg DP, Hillier VF. A scaled version of the General Health
Questionnaire. Psychol Med 1979;9:139‑45.
13. Taghavi S. Evaluation of validity and reliability of General Health
Questionnaire (GHQ). J Psychol 2002;5:381‑98.
14. Gammon J, Hunt J, Musselwhite C. The stigmatisation of source
isolation: A literature review. J Res Nurs 2019;24:677‑93.
15. Brooks SK, Webster RK, Smith LE, Woodland L, Wessely S,
Greenberg N, et al. The psychological impact of quarantine
and how to reduce it: Rapid review of the evidence. Lancet
16. Purssell E, Gould D, Chudleigh J. Impact of isolation on
hospitalised patients who are infectious: Systematic review with
meta‑analysis. BMJ Open 2020;10:e030371.
17. Sharma A, Pillai DR, Lu M, Doolan C, Leal J, Kim J, et al. Impact
of isolation precautions on quality of life: A meta‑analysis. J Hosp
Infect 2020;105:35‑42.
18. Xiao H, Zhang Y, Kong D, Li S, Yang N. Social Capital and sleep
quality in individuals who self‑isolated for 14 days during the
coronavirus disease 2019 (COVID‑19) outbreak in January 2020
in China. Med Sci Monit 2020;26:e923921.
19. Moghadam Tabrizi F. A survey of effective factors on mental
health of employed women in Urmia. J Urmia Sch Nurs Midwifery
20. Noorbala AA, Bagheriyazdi SA, Yasamy MT, Mohammadi K.
Mental health survey of the adult population in Iran. Br J
Psychiatry 2004;184:3‑70.
21. Zhang W, Wang K, Yin L, Zhao W, Xue Q, Peng M, Min B,
Tian Q, Leng H, Du J, Chang H, Yang Y, Li W, Shangguan F,
Yan T, Dong H, Han Y, Wang Y, Cosci F, Wang H: Mental
Health and Psychosocial Problems of Medical Health Workers
during the COVID‑19 Epidemic in China. Psychother Psychosom
2020;89:242‑250. doi: 10.1159/000507639.
22. Lai J. Factors associated with mental health outcomes among
health care workers exposed to coronavirus disease 2019. JAMA
Netw Open 2020;3:e203976.
23. Mazza C. A nationwide survey of psychological distress among
Italian people during the COVID‑19 Pandemic: Immediate
psychological responses and associated factors. Int J Environ Res
Public Health 2020;17:3165.
24. Wang C, Pan R, Wan X, Tan Y, Xu L, Ho CS, et al. Immediate
psychological responses and associated factors during the initial
stage of the 2019 coronavirus disease (COVID‑19) epidemic
among the general population in China. Int J Environ Res Public
Health 2020;17:1729.
25. Ozdin S, Bayrak Ozdin S. Levels and predictors of anxiety,
depression and health anxiety during COVID‑19 pandemic in
Turkish society: The importance of gender. Int J Soc Psychiatry
26. Chen Y, Zhou H, Zhou Y, Zhou F. Prevalence of self‑reported
depression and anxiety among pediatric medical staff
members during the COVID‑19 outbreak in Guiyang, China.
Psychiatry Res 2020;288:113005.
27. Gao J, Zheng P, Jia Y, Chen H, Mao Y, Chen S, et al. Mental health
problems and social media exposure during COVID‑19 outbreak.
PLoS One 2020;15:e0231924.
28. Cao W, Fang Z, Hou G, Han M, Xu X, Dong J, et al. The
psychological impact of the COVID‑19 epidemic on college
students in China. Psychiatry Res 2020;287:112934. doi: 10.1016/j.
psychres. 2020.112934.
29. Saberian M, Hajiaghajani S, Ghorbani R, Behnam B, Maddah S.
The mental health status of employees in Semnan University of
Medical Sciences (1385). Koomesh 2007;8:85‑92.
30. Liu N. Prevalence and predictors of PTSS during COVID‑19 outbreak in China hardest‑hit areas: Gender differences matter.
Psychiatry Res 2020;287:112921.
31. Hawryluck L, Gold WL, Robinson S, Pogorski S, Galea S, Styra R.
SARS control and psychological effects of quarantine, Toronto,
Canada. Emerg Infect Dis 2004;10:1206‑12.
32. Marjanovic Z, Greenglass ER, Coffey S. The relevance of
psychosocial variables and working conditions in predicting
nurses’ coping strategies during the SARS crisis: An online
questionnaire survey. Int J Nurs Stud 2007;44:991‑8.
33. Reynolds DL, Garay JR, Deamond SL, Moran MK, Gold W,
Styra R. Understanding, compliance and psychological
impact of the SARS quarantine experience. Epidemiol Infect
34. Yang L, Wu D, Hou Y, Wang X, Dai N, Wang G, et al. Analysis of
psychological state and clinical psychological intervention model
of patients with COVID‑19. medRxiv 2020; published online
March 24. DOI: 10.1101/2020.03.22.20040899 (preprint).
35. Soheylizad M, Moeini B. Social media: An opportunity for
developing countries to change healthy behaviors. HEHP 2019;7:57‑8.