Document Type : Original Article

Authors

1 Department of Physiology, MGM Medical College, Indore

2 Department of Pharmacology, Government Medical College, Chhindwara, Madhya Pradesh, India

Abstract

INTRODUCTION: Association of ABO blood type with body mass index (BMI) was explored in the
past studies, but literature on association of novel obesity markerssuch as total body fat and lean
body mass (LBM) is scarce. The present study aimed to evaluate the relationship of ABO blood
types with novel obesity markers in normal adolescents.
MATERIALS AND METHODS: A cross‑sectional study was done on 387 medical students. Bioimpedance analysis (BIA)‑derived novel obesity markers such as body fat percent (BFP) and lean
body mass (LBM) were recorded. Blood typing was done using slide‑agglutination method. Mean
and SD were calculated; analysis of variance and Chi‑square (χ2
) correlation were used to determine
the relationship between ABO blood types and obesity markers.
RESULTS: Highest propensity for BFP and LBM was seen in blood groups AB and B (25.09 ± 8.92
and 44.45 ± 6.91) respectively. Highly significant (P < 0.001) differences were observed in the values
of BFP and LBM in normal and obese participants across ABO blood types. Prevalence of obesity
did not show significant relationship (χ2 = 2.069; P = 0.913) with ABO blood types.
CONCLUSIONS: Unlike BMI, novel obesity markers (BFP and LBM) significantly differ across ABO
blood groups in normal and obese population. The findings suggest that ABO blood type might have
role in determining body composition. This will be helpful in recognition of the participants at the risk
of obesity on the basis of their blood groups.

Keywords

1. Ewald DR, Sumner SC. Blood type biochemistry and human
disease. Wiley Interdiscip Rev Syst Biol Med 2016;8:517‑35.
2. Liumbruno GM, Franchini M. Beyond immunohaematology: The
role of the ABO blood group in human diseases. Blood Transfus
2013;11:491‑9.
3. Wang Z, Liu L, Ji J, Zhang J, Yan M, Zhang J, et al. ABO blood
group system and gastric cancer: A case‑control study and
meta‑analysis. Int J Mol Sci 2012;13:13308‑21.
4. Afoakwah R, Aubyn E, Prah J, Nwaefuna EK, Boampong JN.
Relative susceptibilities of ABO blood groups to Plasmodium
falciparum malaria in Ghana. Adv Hematol 2016;2016:5368793.
5. Rush EC, Goedecke JH, Jennings C, Micklesfield L, Dugas L,
Lambert EV, et al. BMI, fat and muscle differences in urban
women of five ethnicities from two countries. Int J Obes (Lond)
2007;31:1232‑9.
6. Kagawa M, Kerr D, Uchida H, Binns CW. Differences in the
relationship between BMI and percentage body fat between
Japanese and Australian‑Caucasian young men. Br J Nutr
2006;95:1002‑7.
7. Romero‑Corral A, Somers VK, Sierra‑Johnson J, Thomas RJ,
Collazo‑Clavell ML, Korinek J, et al. Accuracy of body mass
index in diagnosing obesity in the adult general population. Int
J Obes (Lond) 2008;32:959‑66.
8. Aboel‑Fetoh NM, Alanazi AR, Alanazi AS, Alruwili AN. ABO
blood groups and risk for obesity in Arar, Northern Saudi Arabia.
J Egypt Public Health Assoc 2016;91:169‑73.
9. Jafari E, Sebghatollahi V, Kolahdoozan S, Elahi E, Pourshams A.
Body mass index and ABO blood groups among different
ethnicities of the Golestan cohort study subjects. Govaresh
2012;17:50‑4.
10. Sukalingam K, Ganesan K. Rhesus blood groups associated
with risk to obesity and diabetes mellitus: A report on Punjabi
population in Selangor, Malaysia. Int J Intger Med Sci 2015;2:105‑9.
11. Mmom FC, Chuemere AN. Study of incidence and prevalence
of hypertension, diabetes and obesity with blood type in
postmenopausal females in Port Harcourt. Saudi J Biomed Res
2016;1:22‑9.
12. Anjos LA, Teixeira Fda C, Wahrlich V, Vasconcellos MT, Going SB.
Body fat percentage and body mass index in a probability sample
of an adult urban population in Brazil. Cad Saude Publica
2013;29:73‑81.
13. Dudeja V, Misra A, Pandey RM, Devina G, Kumar G, Vikram NK,
et al. BMI does not accurately predict overweight in Asian Indians
in Northern India. Br J Nutr 2001;86:105‑12.
14. Behera S, Sahoo A, Satyanarayana P. Relationship of blood group
with body fat percentage, visceral fat, and waisthip ratio. Natl J
Physiol Pharm Pharmacol 2016;6:591‑5.
15. ChandraT, GuptaA. Association and distribution of hypertension,
obesity and ABO blood groups in blood donors. Iran J Ped
Hematol Oncol 2012;2:140‑5.
16. Nwafor A, Onugha PI. Association of ABO and Rh blood groups,
haemoglobin genotype and diabetes mellitus in diabetic and
non‑diabetic sticklers in a population of Nigerians. Afr J Appl
Zool Environ Biol 2001;3:26‑30.
17. Bener A, Yousafzai MT. The distribution of the ABO blood groups
among diabetes mellitus patients in Qatar. Niger J Clin Pract
2014;17:565‑8.
18. Anthropometry Procedures Manual; 2007. Available from:
http://www.cdc.gov/nchs/data/nhanes/nhanes_07_08/
manual_an.pdf. [Last accessed on 2018 Nov 07].
19. World Health Organization. (WHO) Steering Committee. The
Asia – Pacific Perspective: Redefining Obesity and its Treatment.
Health Communications Australia Pty Ltd.; 2000.
20. Lewis SM, Bain JB, Imelda B. Dacie and Lewis Practical
Haematology. 10th ed.: Philadelphia (PA): Churchill Livingstone;
2007. p. 499.
21. Bioelectrical impedance analysis in body composition
measurement: National institutes of health technology assessment
conference statement. Am J Clin Nutr 1996;64:524S‑32S.
22. Turki A, Alrasheed K, Omar B, Alfraidy MA. Relation between
ABO blood groups and obesity in a Saudi Arabian population.
J Taibah Univ Med Sci 2017;12:407‑41.
23. Bhattacharya S, Gangaraja B, Bhatt R. Corerelation between the
blood groups, BMI and prehypertension among medical students.
J Chin Clin Med 2010;5:78‑82.
24. Abdollahi AA, Qorbani M, Salehi A, Mansourian M. ABO blood
groups distribution and cardiovascular major risk factors in healthy population. Iran J Publ Health 2009;38:123‑6.
25. Qunq YA. Abdel Hamid AZ. ABO blood group associations
with obesity in random samples from advanced medical
and dental institute staff and students. Biohealth Sci Bull
2012;4:18‑23.
26. Smith S, Okai I, Abaidoo CS, Acheampong E. Association of ABO
blood group and body mass index: A cross‑sectional study from
a Ghanaian population. J Nutr Metab volume 2018;.1‑6. Article
ID8050152, doi.org/10.1155/2018/8050152
27. Lear SA, Humphries KH, Kohli S, Birmingham CL. The use of
BMI and waist circumference as surrogates of body fat differs by
ethnicity. Obesity (Silver Spring) 2007;15:2817‑24.