Document Type : Original Article
Authors
- . Zeinab Hemati 1
- . Mahin Hashemipour 2
- . Silva Hovsepian 3
- . Marjan Mansourian 4
- . Masoud Zandieh 5
- . Mahshid Ahmadian 5
- . Marzie Dalvi 5
- . Serajoddin Arefnia 6
- . Roya Kelishadi 7
1 Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-Communicable Disease, Isfahan University of Medical Sciences, School of Nursing and Midwifery, Isfahan University of Medical Science
2 Isfahan Endocrine and Metabolism Research Center, Isfahan University of Medical Sciences
3 Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-Communicable Disease, Isfahan University of Medical Sciences Department of Pediatrics, Emam Hossein Children's Hospital, Isfahan Univer
4 Department of Biostatistics and Epidemiology, School of Health, Isfahan University of Medical Sciences
5 Isfahan Health Center, Colleague of Congenital Hypothyroidism Screening Program, Isfahan University of Medical Sciences, Isfahan, Iran
6 Department of Pediatrics, Emam Hossein Children's Hospital, Isfahan University of Medical Sciences
7 Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-Communicable Disease, Isfahan University
Abstract
BACKGROUND: Considering the high prevalence rate of congenital hypothyroidism CH in Iran, an
epidemiological study in each region would be helpful in understanding the etiology of the disorder
and providing preventative strategies in this field. This study aims to determine the prevalence of
CH in different cities of the Isfahan province.
MATERIALS AND METHODS: This descriptive and retrospective study was conducted among 918
primarily diagnosed CH neonates, who have been identified through the neonatal screening program
from 2009 to 2015. At the age of ≥3 years, treatment was discontinued for 4 weeks, and T4 and
thyroid‑stimulating hormone were measured. Permanent (PCH) or transient (TCH) was determined
from the results of the thyroid function tests.
RESULTS: From 389,101 screened neonates, 918 were diagnosed with primary CH. The overall
prevalence rate of CH was 2.36 in 1000 live birth (ranged 1.58–7.22 in 1000 live birth in different
cities). The highest prevalence rate of CH was reported in Ardestan, Khansar, Golpaygan, and Nain
cities with prevalence rate of 4.86–7.22 in 1000 live birth and lowest prevalence occurring in Fereydan,
Shahreza, Isfahan, and Mobarakeh cities with prevalence rate of 1.58–1.89 in 1000 live birth. In
392 cases which reached to 3 years of age, the rate of TCH was 47.45%. In Chadegan, Natanz,
Fereydunshahr, Shahinshahr, Najafabad, Dehaghan, Borkhar, and Mobarakeh, the prevalence of
PCH was <50%.
CONCLUSION: The current findings indicate that the incidence rate of both PCH and TCH are
high in Isfahan province with significant variability in different cities which could be due to the role
of different genetic, prenatal, and different environmental factors. These epidemiological data could
be used as baseline date to design more etiological studies.
Keywords
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