Document Type : Original Article
Authors
- . Neda Mostofizadeh
- . Mahin Hashemipour
- . Marjan Roostazadeh
- . Elham Hashemi‑Dehkordi
- . Armindokht Shahsanai 1
- . Mohsen Reisi 2
1 Community and Family Medicine Department, Isfahan University of Medical Sciences, Isfahan University of Medical Sciences
2 Pediatric Pulmonology, Isfahan University of Medical Sciences, Isfahan, Iran
Abstract
BACKGROUND: Type 1 diabetes mellitus (T1DM) and its related comorbidities are considered an
important health issue. This study aimed to evaluate the impact of glycemic control on lipid profile
variables in children with T1DM.
MATERIALS AND METHODS: This study included 274 children (≤19 years of age) with T1DM who
had referred to the outpatient clinics of endocrinology in Emam‑Hossein Hospital of Isfahan, Iran.
Based on American Diabetes Association criteria, patients were divided into two groups including
optimal glycemic control (OGC) and poor glycemic control (PGC). Mean lipid level and frequencies
of lipid profile abnormalities between the two studied groups were compared.
RESULTS: Mean age of the studied population was 13 ± 5.9 years and 133 (48.5%) were boys. A total
of 162 (59.1%) and 112 (40.9%) patients had PGC and OGC, respectively. Hypercholesterolemia was
the most common dyslipidemia in both groups (33 [29.1%] of OGC and 63 [39.1%] of PGC patients).
The frequency of high low‑density lipoprotein (LDL) was significantly higher in patients with PGC
than those with OCG (P = 0.007). The frequencies of hypercholesterolemia, hypertriglyceridemia,
and low levels of high‑density lipoprotein were also higher in PGC group, but did not reach the
significant threshold.
CONCLUSION: It is suggested that glycemic control is in association with lipid profile abnormality
in patients with T1DM. High LDL was significantly more frequent in patients with PGC than those
with OGC. It is recommended to investigate the role of glycemic control on other cardiometabolic
risk factors of T1DM patients. Our findings could be used for planning preventative strategies for
reducing T1DM‑related cardiovascular disease.
Keywords
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