Document Type : Original Article



Background: Neonatal conjunctivitis leads to several ocular consequences in the affected
neonates such as blindness. Currently available therapeutic options include NaNO3,
Gentamicin, Neomycin and so on, in which each of them has their own limitations. Regarding
the immunologic content of colostrum and its safety and easy accessibility, we aimed to
evaluate its preventive effects against neonatal conjunctivitis. Materials and Methods: In
this clinical trial, conducted from November 2011 to July 2012, 300 preterm neonates, with
culture negative eye swab, were enrolled and randomly assigned into three groups. The
intervention group received two drops of colostrum. Control group received no treatment and
other neonates were treated with topical Erythromycin ointment (0.5%). All neonates were
followed for occurrence of clinical conjunctivitis for 28 days. Data analysis were performed by
Chi-square test. Results: Our data demonstrate the beneficial preventive effects of Colostrum
against neonatal conjunctivitis (P = 0.036). Conclusion: Colostrum is suggested as an
alternative prophylactic option for antibiotics against neonatal conjunctivitis. As colostrum is
easily accessible without cost, potential hazards and side effects, public education about its
topical favorable effects is worthwhile.


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