Journal of Education and Health Promotion

Hormonal and reproductive risk factors associated with breast cancer in Isfahan patients

Document Type : Original Article

Authors

. Mehdi Tazhibi
. Mohsen Dehghani 1
. Shadi Babazadeh 2
. Fariborz Makkarian 3
. Maryam Tabatabaeian 4
. Masoumeh Sadeghi 5
. Parisa Rezaei 6
. Mehri Faghihi 6

1 Department of Epidemiology, Shahroud University of Medical Sciences, Shahroud

2 Department of Radiotherapy Oncology, Breast Cancer Study Group, Seiedo-Shohada Hospital

3 Department of Internal Medicine, Breast Cancer Study Group, School of Medicine,

4 Department of Surgery, Breast Cancer Study Group, Seiedo-Shohada Hospital

5 Research Center for Modeling in Health, Institute for Futures Studies in Health, Department of Epidemiology and Biostatistics, Kerman University of Medical Sciences, Kerman, Iran

6 Department of Pathology, Breast Cancer Study Group, Seiedo-Shohada Hospital

Abstract
Background: Breast cancer is the most prevalent type of cancer among Iranian females;
it is noteworthy that the condition of this type of cancer among Iranian women does not
significantly differ from what has been reported from other countries. Considering the
importance of this issue, identification of the backgrounds factors and risk factors of the
breast cancer risk are highly needed. Therefore, the present study is aimed to compare
the risk factors of resident patients of Isfahan province, Iran, with accredited risk factors by
other countries and also identify the importance of each factor in the incidence of cancer.
Materials and Methods: The present work is a case-control study, which was conducted
in 2011. In order to conduct the study, 216 women who had been clinically identified with
breast cancer were selected from Seiedo-Shohada Hospital, Isfahan, Iran, as the case group.
Moreover, 41 healthy women who were the relatives of the selected patients (i.e., sisters and
aunts) were selected as the control group. The data and information of the patients from
1999 to 2010 were collected from either assessing the database system of the center for breast
cancer research or interviewing the patients through phone. To analyze the data, multiple
logistic regression method was applied. Results: The range of age among selected individuals
in this study was from 20-75 years old. The determinant factors for odds of breast cancer
included in the applied multiple logistic regression model were the use of oral contraceptive
pills (OCPs) (odds ratio [OR] =0.18, 95% confidence interval [CI] = 0.04-0.75) as the protective
factor, hormone replacement therapy (OR = 10.2, 95% CI = 1.18-88.89) and menopause at
old age (OR = 1.26, 95% CI = 1.11-2.12) as the risk factors. Furthermore, there was not seen
any significant relationship between age, vocation, and marital status with odds of breast
cancer in multiple model. Conclusion: Based
on the results, use of OCPs as protective
factor, hormone replacement therapy, and
menopause at old age are identified as the
risk factors in developing breast cancer
among women. Influencing and modifiable
factors should be considered very important
in society based interventions and preventive
interventions planning.

Keywords

Breast cancer
case-control
hormone
Isfahan
reproductive
risk factors
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Journal of Education and Health Promotion
Volume 4, Issue 3
Spring 2014
Pages 1-5

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