Document Type : Original Article


1 Department of Radiation Oncology, and Breast Cancer Research Center

2 Department of Surgery and Breast Cancer Research Center

3 Department of Pathology and Breast Cancer Research Center

4 Pathology Department and Breast Cancer Research Center, Isfahan University of Medical Sciences, Isfahan, Iran


Background: Breast cancer is the most common cause of death in women in the age range
of 35‑55 years. Each year, one or two cases of breast cancer per 1000 women are diagnosed
as new cases. Despite the serious prognosis and high rate of morbidity, mortality, and
pathogenicity, in the case of early diagnoses, the prognosis will be better. The aim of this
study was to investigate the age trends in breast cancer patients with different sizes of tumors
in Breast Cancer Research Center of Isfahan University of Medical Sciences in 2001‑2010.
Materials and Methods: The information in radiotherapy and oncology of Isfahan University of
Medical Sciences and Milad Hospital from 2001 to 2010 were coded and analyzed. Frequency
of patients’ age groups, tumor sizes and the year of cancer diagnosis were calculated.
Correlation test was used for data analysis in statistical analysis in social science (SPSS)
software version 18. Findings: Among the 3722 patients with breast cancer, the highest
relative frequency distribution, respectively was observed in the age of 40‑49 years (34.4%),
50‑59 years (26.6%), 30‑39 years (17.7%), 60‑69 years (13.2%), 20‑29 years (2.5%), 70 years
and older (5.2%) and less than 20 years. Relative frequency distribution of tumor sizes in a
variety of 5 cm (T2) was with the frequency of 59.8%, and then 26% at 5 cm (T3), 10.5% at
2 cm (T1), 3.1% at T4 and 0.6 at In‑situ, respectively. Conclusion: The investigation of age
trends showed that diagnosis rate of breast cancer increased from 2001 to 2004. It reached its
highest value in 2006 at the age range of 30‑39 years. Then, the trend has been downward, and
it has continued to decline until 2010, which
could be the result of the equipping screening
system and recording the malignant cases.
85.8% of the examined tumors in T2 and T3
group were visible and may be disturbing.
Comparing the frequency distribution of the
infected population showed that the highest
incidence of breast cancer diagnosis were in
the age range of 40‑49 years. It seems that as
long as the mass has not reached an obvious
palpable state, it has not been diagnosed.


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