1 Department of Midwifery, School of Nursing and Midwifery, Evidence-Based Care Research Center, School of Nursing and Midwifery, Mashhad University of Medical Sciences

2 Department of Clinical Psychology, Research Center for Psychiatry and Behavioral Sciences, Mashhad University of Medical Sciences

3 Department of Biostatistics, Faculty of Public Health, Research Center for Management and Social Factors Influencing Health, Mashhad University of Medical Sciences,

4 Department of Obstetrics and Gynecology, Research Center for Women’s Health, Faculty of Medicine, Mashhad University of Medical Sciences,

5 Department of Clinical Psychology, Ebne Sina Hospital, Mashhad University of Medical Sciences, Mashhad, Iran


INTRODUCTION: Using fertility treatment will cause high levels of anxiety and depression. The study
was carried out with the objective of determining the effect of problem‑solving skills (PSS) training on
mental health and the success of treatment of infertile women under intrauterine insemination (IUI)
MATERIALS AND METHODS: this randomized clinical trial was carried out on 72 women
referring to Milad Infertility Center in Mashhad. Individuals were randomly assigned into control and
intervention groups. PSS were taught in three sessions in the intervention group, and the control
group received usual care. The success rate of therapy and the mean of anxiety and depression
on the day of IUI operation were compared using the Beck Depression Inventory and Spielberger
Anxiety Inventory in both groups. t‑test, Mann–Whitney, paired t‑test, Wilcoxon, and Chi‑square
tests were used to analyze the data.
RESULTS: on the day of IUI operation, the mean score of state anxiety in the control
group (5 0 . 11 ± 8.51) and PSS (68.12 ± 11.49) was significant (P < 0.001), trait anxiety in the
control group (46.41 ± 8.70) and PSS (44.00 ± 9.92) was significant (P < 0.001), and depression in the
control group (17.44 ± 11.70) and PSS (12.99 ± 8.99) was significant (P < 0.001); however, the success
of treatment in both groups (14.7% and PSS (26.5%) was not significantly different (P = 0.230).
CONCLUSION: Considering the effect of problem‑solving on reducing anxiety and depression, it is
suggested that infertility center of this intervention should be used.


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