1 Department of Internal Medicine, School of Medicine, Yasuj University of Medical Sciences, Yasuj

2 Gastrointestinal and Hepatobiliary Diseases Research Center, Poursina Hakim Research Institute for Health Care Development, Isfahan,

3 Molecular Clinical Microbiology Subdivision, Clinical Pathology Division, Department of Pathology, School of Medicine, Shiraz University of Medical Sciences, Clinical Education Research Center, Shiraz University of Medical Sciences, Shiraz, Iran


CONTEXT AND AIMS: We aimed to evaluate the effectiveness of hydroalcoholic extract of Quercus
brantii’s nut on clinical, endoscopic, and pathological findings of patients with dyspepsia.
PATIENTS AND METHODS: In this randomized, double-blind clinical trial, patients with symptomatic
dyspepsia who had an endoscopic evaluation for dyspepsia were included and randomized into two
groups. One Group (A) received drug extract with a dose of 100 mg twice a day for 10 days. Group B,
as a control group, received placebo. Immediately and 2 months after intervention, the patients were
followed up, and the characteristics of their dyspepsia (severity and frequency), endoscopic and
pathologic fi ndings were reevaluated and compared.
RESULTS: In this trial, 13 and ten patients participated in the study in Groups A and B, respectively.
Two months after intervention, ten (76.9%) and six (60%) participants referred for follow-up
and endoscopic evaluation. There were no signifi cant changes in clinical presentations after
intervention (P > 0.05). Two months after intervention, clinical presentations including severity and
frequency of epigastric pain had signifi cant decrease in Group A and endoscopic evaluation indicated
signifi cant improvement in Group A (P < 0.05). Pathologic fi ndings were similar and not signifi cantly
different in two studied groups after intervention (P > 0.05).
CONCLUSIONS: The fi ndings of this trial indicated that hydroalcoholic extract of Q. brantii’s nut
could have delayed signifi cant proper effect on clinical and endoscopic presentations of patients
with dyspepsia. We recommend that this study should be considered as pilot one in this fi eld. The
results could be used as baseline data for more interventional studies. More surveys are needed to
investigate the mechanism of extract action at molecular basis.


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