Authors

1 Department of Pathology, School of Medicine, Shiraz University of Medical Sciences,

2 Transplant Research Centre, Shiraz University of Medical Sciences

3 Department of Pathology, School of Medicine, Shiraz University of Medical Sciences Clinical Education Center, Shiraz University of Medical Sciences, Shiraz, Iran

4 Department of Pathology, School of Medicine, Shiraz University of Medical Sciences

Abstract

Atypical teratoid rhabdoid tumor (ATRT) is a rare malignant tumor with gloom destiny. Our case was
a 4‑year‑old boy with a temporal lobe tumor that was then became evident of ATRT with recurrent
happening. In a retrospective review of all cytologic slides, we found unique rhabdoid cells that are
morphologically evident cells for ATRT in both times. Unfortunately, the cells were overlooked at the
first time. We conclude if the pathologist is experienced to see rhabdoid cells noticing these cells is
highly helpful for diagnosis ATRT, especially in frozen sectioning.

Keywords

1. Zarovnaya EL, Pallatroni HF, Hug EB, Ball PA, Cromwell LD,
Pipas JM, et al. Atypical teratoid/rhabdoid tumor of the spine in
an adult: Case report and review of the literature. J Neurooncol
2007;84:49‑55.
2. Chan KH, Mohammed Haspani MS, Tan YC, Kassim F. A case
report of atypical teratoid/rhabdoid tumour in a 9‑year‑old girl.
Malays J Med Sci 2011;18:82‑6.
3. Chen YW, Wong TT, Ho DM, Huang PI, Chang KP, Shiau CY,
et al. Impact of radiotherapy for pediatric CNS atypical teratoid/
rhabdoid tumor (single institute experience). Int J Radiat Oncol
Biol Phys 2006;64:1038‑43.
4. Güner G, Önder S, Söylemezoglu F. Cytomorphological features
of atypical teratoid/rhabdoid tumor: An account of 12 years’
experience. Diagn Cytopathol 2014;42:856‑62.
5. Parwani AV, Stelow EB, Pambuccian SE, Burger PC, Ali SZ.
Atypical teratoid/rhabdoid tumor of the brain: Cytopathologic
characteristics and differential diagnosis. Cancer 2005;105:65‑70.
6. Tekautz TM, Fuller CE, Blaney S, Fouladi M, Broniscer A,
Merchant TE, et al. Atypical teratoid/rhabdoid tumors (ATRT):
Improved survival in children 3 years of age and older with
radiation therapy and high‑dose alkylator‑based chemotherapy.
J Clin Oncol 2005;23:1491‑9.
7. Hanna SL, Langston JW, Parham DM, Douglass EC. Primary
malignant rhabdoid tumor of the brain: Clinical, imaging, and
pathologic findings. AJNR Am J Neuroradiol 1993;14:107‑15.
8. Lee YK, Choi CG, Lee JH. Atypical teratoid/rhabdoid tumor of the
cerebellum: Report of two infantile cases. AJNR Am J Neuroradiol
2004;25:481‑3.
9. Krishnani N, Kumari N, Behari S, Rana C, Gupta P. Intraoperative
squash cytology: Accuracy and impact on immediate surgical
management of central nervous system tumours. Cytopathology
2012;23:308‑14.
10. Brommeland T, Lindal S, Straume B, Dahl IL, Hennig R. Does
imprint cytology of brain tumours improve intraoperative
diagnoses? Acta Neurol Scand 2003;108:153‑6.