. Nehleh Parandavar; . Mohsen Hojat; . Khadijeh Abdali; . Sara Keshtgar; . Masoumeh Emamghoreishi; . Babak Shirazi Yeganeh
Volume 8, Issue 11 , November 2018, , Pages 1-7
Abstract
BACKGROUND: Cardiovascular diseases are the major public health problem in many countriesand are responsible for more than half of the deaths in above 50‑year‑old women. The most ...
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BACKGROUND: Cardiovascular diseases are the major public health problem in many countriesand are responsible for more than half of the deaths in above 50‑year‑old women. The most commoncurable risk factor of these disorders is hypoestrogenemia resulting from menopause. The presentstudy aimed to investigate the effect of melatonin on plasma lipid levels in menopausal women.MATERIALS AND METHODS: The present double‑blind, placebo‑controlled, clinical trial wasconducted in 2013–2014 on 240 menopausal women between 40 and 60 years old referring tothe Gynecology and obstetrics clinics of Shiraz University of Medical Sciences who were randomlydivided into two groups. The intervention group received 3 mg melatonin tablets and the controlgroup received the placebo for 3 months. The data were gathered using the demographic informationquestionnaire and lipid profile test before and 3 months after the intervention. Then, the data wereanalyzed through the SPSS statistical software (version 16). The repeated measures analysis ofvariance, the least significant difference, the independent‑sample t, the Chi‑square, and Fisher’sexact tests were done for data analysis.RESULTS: The two study groups were similar regarding the demographic and clinical variablesat the beginning of the study. In the melatonin group, the amount of triglyceride increased from140.34 ± 48.29 before the study to 151.24 ± 54.60 3 months after the intervention and no significantdifference was observed between the two groups in this regard (confidence interval [CI] = 95%,P > 0.05). In addition, no significant difference was found between the two groups concerninglow‑density lipoprotein cholesterol level (CI = 95%, P = 0.125).CONCLUSION: Melatonin was not effective in reduction of lipid levels. However, further controlledstudies are needed to be conducted on the issue.
