. Mohammadreza Modaresi; . Ali Pourvali; . Gholamreza Azizi; . Reza Rezaee Taher; . Tina Alinia; . Mohsen Reisi
Volume 8, Issue 8 , August 2018, , Pages 1-4
Abstract
BACKGROUND: Some evidence suggests that childhood croup could be associated with increasedincidence of adulthood bronchial reactivity, but its significance is uncertain. The aim of ...
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BACKGROUND: Some evidence suggests that childhood croup could be associated with increasedincidence of adulthood bronchial reactivity, but its significance is uncertain. The aim of the presentstudy was to evaluate the long‑term outcome of early life croup.PATIENTS AND METHODS: This case–control study was conducted in 2010–2012 in Isfahan,Iran. The case group consisted of 164 adolescents with a history of severe croup in early life and anequal number of healthy controls without any history of croup or other chronic or recurrent respiratorydiseases. The two groups were compared according to pulmonary function tests and bronchialreactivity (exercise challenge test). Statistical analyses were performed using the SPSS softwarepackage, version 20 (SPSS Inc., Chicago, IL, USA). P < 0.05 was considered significant.RESULTS: Baseline spirometric values (forced expiratory volume in 1st s (FEV1), forced volumecapacity (FVC), FEV1/FVC, and forced expiratory flow at 25%–75% (FEF25–75) were similar in caseand control groups. A reduction in FEV1 and FEF25–75 after exercise challenge test was seen in9% and 12.8% of patients, respectively, whereas this was reduced in only 4.2% and 6.1% of thecontrols (P = 0.034 and P = 0.021, respectively).CONCLUSION: Our findings suggest that childhood croup might be a predisposing factor for bronchialhyperreactivity in adulthood. Longitudinal studies are necessary to confirm the clinical significanceof these findings.