. Mohammadhossein Arjmandnia; . Mahsa Besharati; . Sajad Rezvan
Volume 8, Issue 4 , April 2018, , Pages 1-4
Abstract
Abstract:CONTEXT: Congenital heart disease (CHD) is an important cause of death during the 1st year of lifeand includes a special group of cardiac diseases that exist from birth. These ...
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Abstract:CONTEXT: Congenital heart disease (CHD) is an important cause of death during the 1st year of lifeand includes a special group of cardiac diseases that exist from birth. These conditions arise due tothe abnormal development of an embryo’s normal structures.AIMS: A case–control study was conducted to investigate the determinant factors leading to CHD.MATERIALS AND METHODS: All newborns who have been diagnosed with CHD uponechocardiography in 2013 were considered as cases. The number of samples required was randomlyselected from the newborns who lacked CHD on cardiography. The mothers of both groups werehanded the questionnaires.STATISTICAL ANALYSIS USED: SPSS 23 was employed to analyze the data.RESULTS: A statistically significant association was seen between CHD and a positive familyhistory (FH) (P < 0.001), consanguinity (P < 0.001), maternal diabetes (P = 0.004), the useof antiepileptics during the first 45 days of gestation (P = 0.002), and the mother’s educationstatus (P > 0.001). No significant association was observed between CHD in the newborn and the agebelow 20 and above 35 years and (P = 0.11), maternal body mass index (BMI) (P = 0.44), smokingduring the first 45 days of gestation (P = 0.017), and maternal rheumatologic diseases (P = 0.4).CONCLUSIONS: Newborns are at a greater risk of having CHD born from mothers with a FH ofCHD, from consanguineous marriages, history of diabetes, antiepileptic use, and lack of folic aciduse. However, no significant associations were found between newborn CHD and maternal age,BMI, or cigarette smoking.