. Zahra Fazeli Dehkordi; . Mehdi Tazhibi; . Shadi Babazade
Volume 4, Issue 5 , November 2014, , Pages 1-10
Abstract
Background and Objectives: Breast cancer is a major threat to women’s health. Evaluationof the changes in trend of the incidence rate provides valuable information for the assessmentand ...
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Background and Objectives: Breast cancer is a major threat to women’s health. Evaluationof the changes in trend of the incidence rate provides valuable information for the assessmentand planning of development indicators of each country. The aim of the present study was toapply the JoinPoint regression model for determining changes in the trend of the breast cancerincidence rate in Isfahan. Materials and Methods: In this cross‑sectional study, 3640 womenwith breast cancer referring to oncology and radiotherapy departments of Seyed‑al‑Shohadaand Milad cancer treatment centers of Isfahan during 2001–2010 were studied and samplingwas not done. Joinpoint regression model was used to investigate the pattern of breastcancer incidence rate. Response and independent variables were the natural logarithm of theage‑standardized incidence rates and year of diagnosis of breast cancer, respectively, in whichvarious levels of cancer tumor characteristics (P < 0.05) were analyzed. Results: The incidencerates increased annually in the age groups of 40–44 years (6.2%), 45–49 years (5.3%), and55–59 years (5.3%). The trend of incidence rates in women with tumor size ≤2 cm (18.2%),well (moderately) differentiated tumor grade [8% (10.2%)], positive estrogen (progesterone)hormone receptor status [10.5% (6.9%)], and the proportion of positive lymph node to surgerynode ≤25% (nonsignificant) was upward. Conclusion: The trend of incidence rates with tumorsize ≤2 cm, well‑differentiated tumor grade, moderately differentiated tumor grade, and positiveestrogen and progesterone hormone receptors was upward. The pattern of breast cancer canhelp in cancer prevention and prognosis, and in selecting the best type of surgery.
