. Mehdi Tazhibi; . Abdollah Hajivandi; . Arefeh Dehghani Tafti; . Hossein Fallahzadeh
Volume 4, Issue 3 , June 2014, , Pages 1-8
Abstract
Introduction: Hepatitis B infection is an important health problem all over the world, andaccording to the studies, Iran is a country with intermediate prevalence, so vaccination is ...
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Introduction: Hepatitis B infection is an important health problem all over the world, andaccording to the studies, Iran is a country with intermediate prevalence, so vaccination is acost-benefit approach. In this study, evidence about the efficacy of hepatitis B vaccine wascollected by systematic review methods and its amount was estimated by a meta-analysis.Materials and Methods: In this study, documents and literature search were performedusing valid key words in Information Sciences Institute, PubMed, Scientific InformationData base, and Iranmedex databases from 1997 to 2010 in different regions of Iran. Allcross-sectional studies about the efficacy of hepatitis B vaccine in Iran which fulfilledthe inclusion criteria entered the study. Antibody titer (Anti-hemoglobins > 10 IU/L) wasconsidered as the desired efficacy. In order to present the results, prevalence and Forestplot were used and for evaluation of the inconsistency meta-regression model and I2 indexwere used. We used R.15.3.2 software for analysis. Results: Totally 64 studies (52 studiesin general population and 12 studies among specific populations) including 12,575 subjectswith age range from 8 months to 55 years entered the meta-analysis. The efficacy was86.3% (confidence interval [CI]: 83.9-88.7%) in the general population and 59.62% (CI:47.9-71.29%) in specific patient populations. Also the efficacy was significantly related to theyear of publication, age and gender (P < 0.05). Conclusion: Prevention is an important issuein general health. Hepatitis B vaccination is one of the methods used to prevent hepatitisB infection. According to this study, the efficacy of hepatitis B vaccination was more than80% in general population, so injection of full course of hepatitis B vaccinationis enoughand booster dose is not required.
