. Alieh Zamani Kiasari; . Nahid Aghaei; . Goli Aezzi; . Abbas Alipour; . Khadijeh Ghavibonyeh
Volume 12, Issue 1 , January 2022, , Pages 1-7
Abstract
BACKGROUND: Pain and nausea and vomiting are of serious complications following the use ofopiates after surgery, especially cesarean section. Control of postoperative complications ...
Read More
BACKGROUND: Pain and nausea and vomiting are of serious complications following the use ofopiates after surgery, especially cesarean section. Control of postoperative complications is one ofthe necessities of quality promotion of health‑care system. Medications with few side effects suchas corticosteroids including dexamethasone can be an appropriate option. In addition, the route ofadministration can have a significant effect on the effectiveness of the drug. The aim of the presentstudy was to compare the effects of intrathecal with intravenous dexamethasone in reducing thecomplications associated with intrathecal morphine after cesarean section.MATERIALS AND METHODS: The study was a double‑blind randomized controlled clinical trial anddetermined the effect of intrathecal and intravenous dexamethasone on the incidence and severityof complications of intrathecal morphine after cesarean section on 120 patients and its relationshipwith serious complications after surgery. Descriptive and analytical statistics were used to examinethe characteristics of the case and control groups, and STATA SPSS software was used to comparethe two groups.RESULTS: There was no significant association between the two groups in terms of baselinecharacteristics. Pain score in the intrathecal injection group was lower than the intravenous injectiongroup, with a statistically significant difference (P = 0.02). In addition, there was a significantassociation regarding to the incidence of nausea, vomiting, and itching between intrathecal andintravenous injection groups (P = 0.008).CONCLUSION: Dexamethasone was effective to reduce opiate complications after cesarean section.Establishing a suitable association between dexamethasone half‑life, efficacy, type of use, and timeof use can result the best outcomes and promote patients’ satisfaction in cesarean section.
